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. 2018 Sep 10;38:25. doi: 10.1186/s41232-018-0083-8

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Schematic model of transcription factor and signaling molecule interactions in endothelial cell functions. VEGF regulates endothelial cell functions through interaction and association with PI3K-Akt, mTOR, and Notch signaling. Foxo1-dependent (blue) and Foxo1-independent (red) pathways for endothelial cell elongation are shown. Pathway depends on environmental levels of VEGF