Fig. 4.

Local association study between DMRs and genetic variations. a Summary of the associations between DMRs and local siRNA expression variation, TE variation and SNPs. b Plot of methylation levels (x-axis) and siRNA expression values (y-axis). Methylation level and siRNA RPM were mean-centered and normalized. c Correlation between DMR methylation and TE variant state at different distances. The DMR/TE variation pairs were divided into five groups according to the distance between DMR and TE variant. Different letters at the top of each column indicate significant differences by ANOVA (p < 0.001). d The proportion of DMRs associated and not associated with local genetic variations (top) and the proportion of different DMR types (bottom left) and different genetic variation combinations (bottom right) for locally associated DMRs. e An example (Dos_CHG-DMR, Chr14:45,221,203–45,222,398) DMR that was simultaneously associated with local siRNA expression, TE variant, and SNP sites. Rectangles in the TE variant panel indicate reads supporting the TE variant and rectangles in the SNP panel indicate SNP sites