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. Author manuscript; available in PMC: 2019 Aug 20.
Published in final edited form as: Chem Res Toxicol. 2018 Jul 30;31(8):697–711. doi: 10.1021/acs.chemrestox.8b00055

Figure 3.

Figure 3.

Pol κ SNPs retain similar extension activity from the correct base pair as WT pol κ on undamaged DNA templates (A, C) as well as both minor groove (B) and major groove (D, E) DNA adducts with the exception of R219I, R298H, and Y432S, which are less active than WT on all templates. Time points are 0, 20, and 60 min for each variant; quantitation is reported in Table S2.