Table 2.
CMR Findings at Baseline and at 6 Months in 203 Patients With STEMI Grouped According to the Presence of Hemorrhage at 2 Days and the Persistence or Absence of Iron Within the Infarct Zone at 6 Months∗
| All Patients (N = 203) | No Acute Myocardial Hemorrhage (n = 129, 64%) | Acute Myocardial Hemorrhage 6 Months |
p Value† R vs. P |
||
|---|---|---|---|---|---|
| Resolved (R) (n = 30, 49%)‡ | Persistent (P) (n = 44, 59%)‡ | ||||
| CMR findings 2 days post-MI (n = 211) | |||||
| LV ejection fraction, % | 55 ± 10 | 57 ± 8 | 54 ± 9 | 47 ± 10 | 0.004 |
| LV end-systolic volume, ml | |||||
| Men | 76 ± 27 | 68 ± 23 | 78 ± 18 | 94 ± 31 | 0.012 |
| Women | 54 ± 14 | 52 ± 13 | 55 ± 16 | 71 ± 9 | 0.117 |
| Edema and infarct characteristics at 2 days | |||||
| Myocardial edema, % LV mass | 32 ± 12 | 29 ± 11 | 32 ± 10 | 42 ± 11 | <0.001 |
| Infarct size, % LV mass | 18 ± 14 | 12 ± 10 | 22 ± 10 | 33 ± 12 | <0.001 |
| Late microvascular obstruction present | 102 (50) | 30 (23) | 30 (100) | 44 (100) | — |
| Late microvascular obstruction, % LV mass | 2.5 ± 4.4 | 0.5 ± 1.6 | 4.1 ± 2.7 | 7.3 ± 6.4 | 0.005 |
| Myocardial hemorrhage, % LV mass | 8.5 ± 6.1 | — | 5.8 ± 4.0 | 10.3 ± 6.6 | 0.001 |
| Myocardial hemorrhage, % infarct size | 26.9 ± 15.2 | — | 27.2 ± 18.4 | 26.2 ± 12.8 | 0.684 |
| CMR findings 6 months post-MI (n = 211) | |||||
| LV ejection fraction at 6 months, % | 62 ± 10 | 65 ± 7 | 60 ± 7 | 53 ± 11 | 0.001 |
| LV end-systolic volume at 6 months, ml | |||||
| Men | 68 ± 36 | 55 ± 21 | 70 ± 21 | 98 ± 53 | 0.005 |
| Women | 48 ± 17 | 43 ± 15 | 55 ± 11 | 75 ± 14 | 0.045 |
| Infarct characteristics at 6 months | |||||
| Infarct size, % LV mass | 13 ± 10 | 9 ± 8 | 16 ± 7 | 24 ± 10 | <0.001 |
| Myocardial iron, % LV mass | 2.4 ± 2.2 | — | — | 2.4 ± 2.2 | — |
| Myocardial iron, % infarct size | 10.6 ± 9.4 | — | — | 10.6 ± 9.4 | — |
| Myocardial T2* values at 6 months | |||||
| T2* infarct at 6 months, ms | 25.7 ± 4.4 | 27.1 ± 4.0 | 27.0 ± 4.3 | 21.6 ± 2.7 | <0.001 |
| T2* core at 6 months, ms | 16.6 ± 2.1 | — | — | 16.6 ± 2.1 | — |
Values are mean ± SD or n (%).
CMR = cardiac magnetic resonance; LV = left ventricle; MI = myocardial infarction; STEMI = ST-segment elevation myocardial infarction.
∗
Extent of myocardial hemorrhage and variables that differ between the groups are reported. The full table is reported in Online Table 2.
†
The p values were obtained from Student’s t test or Fisher exact test for comparisons between groups with resolved and persistent iron.
‡
Percentage of patients with hemorrhage at 2 days (n = 74).