Table 1.
Baseline Characteristics by Guideline Risk Levels
| ACC/AHA (2012) |
ESC (2013) |
NICE (2016) |
Complete Trial Cohort | ||||
|---|---|---|---|---|---|---|---|
| Low Risk | High Risk | Low Risk | High Risk | Low Risk | High Risk | ||
| PROMISE | |||||||
| Patients | 250 | 9,753 | 251 | 9,752 | 1,002 | 9,001 | 10,003 |
| Age, yrs | 55.0 (52.5–57.7) | 60.3 (54.6–66.2) | 55.0 (52.4–57.7) | 60.3 (54.6–66.2) | 60.3 (54.3–66.5) | 59.9 (54.5–65.9) | 60.0 (54.4–65.9) |
| Female | 250 (100.0) | 5,020 (51.5) | 251 (100.0) | 5,019 (51.5) | 564 (56.3) | 4,706 (52.3) | 5,270 (52.7) |
| BMI, kg/m2 | 30.5 (25.8–35.0) | 29.7 (26.4–33.9) | 30.4 (25.8–35.0) | 29.7 (26.4–33.9) | 29.3 (26.0–33.5) | 29.7 (26.4–34.0) | 29.7 (26.3–33.9) |
| Hypertension | 152 (60.8) | 6,349 (65.1) | 153 (61.0) | 6,348 (65.1) | 611 (61.0) | 5,890 (65.4) | 6,501 (65.0) |
| Hypercholesterolemia | 156 (62.4) | 6,611 (67.8) | 157 (62.5) | 6,610 (67.8) | 654 (65.3) | 6,113 (67.9) | 6,767 (67.7) |
| Diabetes mellitus | 39 (15.6) | 2,105 (21.6) | 39 (15.5) | 2,105 (21.6) | 179 (17.9) | 1,965 (21.8) | 2,144 (21.4) |
| Smoking history, current/ex | 119 (47.6) | 4,985 (51.1) | 119 (47.4) | 4,985 (51.1) | 491 (49.0) | 4,613 (51.3) | 5,104 (51.0) |
| PAD or cerebrovascular disease | 7 (2.8) | 545 (5.6) | 7 (2.8) | 545 (5.6) | 46 (4.6) | 506 (5.6) | 552 (5.5) |
| Family history | 83 (33.3) | 3,119 (32.1) | 83 (33.2) | 3,119 (32.1) | 296 (29.6) | 2,906 (32.4) | 3,202 (32.1) |
| Anginal symptoms | |||||||
| Nonanginal | 250 (100) | 814 (8.3) | 250 (99.6) | 814 (8.3) | 1,002 (100) | 62 (0.7) | 1,064 (10.6) |
| Atypical angina | 0 (0) | 7,773 (79.7) | 1 (0.4) | 7,772 (79.7) | 0 (0) | 7,773 (86.4) | 7,773 (77.7) |
| Typical angina | 0 (0) | 1,116 (12.0) | 0 (0) | 1,166 (12.0) | 0 (0) | 1,166 (13.0) | 1,166 (11.7) |
| Framingham 10-year CVD risk | 8.7 (5.9–12.9) | 17.4 (10.8–28.9) | 8.7 (5.8–12.9) | 17.4 (10.8–28.9) | 15.6 (9.8–26.0) | 17.3 (10.6–28.9) | 17.1 (10.6–28.6) |
| SCOT-HEART | |||||||
| Patients | 528 | 3,242 | 748 | 3,022 | 1,447 | 2,323 | 3,770 |
| Age, yrs | 50.0 (42.0–54.0) | 59.0 (51.0–65.0) | 51.0 (46.0–58.0) | 59.0 (51.0–66.0) | 54.0 (47.0–61.0) | 59.0 (52.0–66.0) | 57.0 (50.0–64.0) |
| Female | 465 (88.1) | 1,256 (38.7) | 727 (97.2) | 994 (32.9) | 669 (46.2) | 1,052 (45.3) | 1,721 (45.6) |
| BMI, kg/m2 | 29.2 (25.0–34.5) | 28.7 (25.7–32.5) | 29.1 (25.0–34.6) | 28.7 (25.7–32.4) | 28.4 (25.1–32.7) | 29.0 (25.9–32.9) | 28.8 (25.6–32.8) |
| Hypertension | 112 (21.5) | 1,099 (34.2) | 179 (24.2) | 1,032 (34.4) | 362 (25.3) | 849 (36.8) | 1,211 (32.4) |
| Hypercholesterolemia | 176 (33.3) | 1,902 (58.7) | 284 (38.0) | 1,794 (59.4) | 580 (40.1) | 1,498 (64.5) | 2,078 (55.1) |
| Diabetes mellitus | 38 (7.2) | 332 (10.2) | 58 (7.8) | 312 (10.3) | 115 (7.9) | 255 (11.0) | 370 (9.8) |
| Smoking history, current/ex | 270 (51.1) | 1,684 (52.0) | 384 (51.3) | 1,570 (52.0) | 736 (50.9) | 1,218 (52.5) | 1,954 (51.9) |
| PAD or cerebrovascular disease | 14 (2.7) | 150 (4.7) | 22 (3.0) | 142 (4.7) | 52 (3.6) | 112 (4.8) | 164 (4.4) |
| Family history | 251 (47.8) | 1,307 (40.7) | 353 (47.6) | 1,205 (40.3) | 580 (40.6) | 978 (42.4) | 1,558 (41.7) |
| Anginal symptoms | |||||||
| Nonanginal | 528 (100.0) | 1,088 (33.6) | 642 (85.8) | 974 (32.2) | 1,447 (100.0) | 169 (7.3) | 1,616 (42.9) |
| Atypical angina | 0 (0.0) | 893 (27.5) | 106 (14.2) | 787 (26.0) | 0 (0.0) | 893 (38.4) | 893 (23.7) |
| Typical angina | 0 (0.0) | 1261 (38.9) | 0 (0.0) | 1261 (41.7) | 0 (0.0) | 1,261 (54.3) | 1,261 (33.4) |
| Framingham 10-yr CVD risk | 6.3 (3.6–9.3) | 16.2 (10.0–25.2) | 7.4 (4.2–11.2) | 16.8 (10.3–25.9) | 11.2 (6.6–18.2) | 16.7 (9.6–27.0) | 14.3 (8.4–23.5) |
Values are n, median (interquartile range), n (%), mean ± SD.
ACC/AHA = American College of Cardiology/American Heart Association; BMI = body mass index; CVD = cerebrovascular disease; ESC = European Society of Cardiology; NICE = National Institute of Health and Care Excellence; PAD = peripheral arterial disease; PROMISE = Prospective Multicenter Imaging Study for Evaluation of Chest Pain; SCOT-HEART = Scottish Computed Tomography of the Heart.