Table 2.
Patient Outcomes by Guideline Risk Levels
| ACC (2012) |
ESC (2013) |
NICE (2016) |
||||
|---|---|---|---|---|---|---|
| Low Risk | High Risk | Low Risk | High Risk | Low Risk | High Risk | |
| PROMISE | ||||||
| Patients | 250 | 9,753 | 251 | 9,752 | 1,002 | 9,001 |
| CAD on CCTA | 108 | 4,433 | 108 | 4,433 | 456 | 4,085 |
| Normal | 55 (50.9) | 1,463 (33.0) | 55 (50.9) | 1,463 (33.0) | 155 (34.0) | 1,363 (33.4) |
| Mild CAD | 50 (46.3) | 2,436 (55.0) | 50 (46.3) | 2,436 (55.0) | 262 (57.5) | 2,224 (54.4) |
| Obstructive CAD | 3 (2.8) | 534 (12.0) | 3 (2.8) | 534 (12.0) | 39 (8.6) | 498 (12.2) |
| Prognostically significant CAD∗ | 0 (0) | 144 (3.2) | 0 (0) | 144 (3.2) | 11 (2.4) | 133 (3.3) |
| Subsequent coronary revascularization—90 days | 3 (1.2) | 468 (4.8) | 3 (1.2) | 468 (4.8) | 23 (2.3) | 448 (5.0) |
| PCI | 3 (1.2) | 361 (3.7) | 3 (1.2) | 361 (3.7) | 22 (2.2) | 342 (3.8) |
| CABG | 0 (0.0) | 107 (1.1) | 0 (0.0) | 107 (1.1) | 1 (0.1) | 106 (1.2) |
| CVD death or nonfatal MI—1 yr | 2 (0.8) | 155 (1.6) | 2 (0.8) | 155 (1.6) | 9 (0.9) | 148 (1.6) |
| SCOT-HEART | ||||||
| Patients | 528 | 3,242 | 748 | 3,022 | 1,447 | 2,323 |
| CAD on CCTA | 193 | 1,426 | 305 | 1,314 | 591 | 1,028 |
| Normal | 138 (71.5) | 498 (34.9) | 198 (64.9) | 438 (33.3) | 296 (50.1) | 340 (33.1) |
| Mild CAD | 46 (23.8) | 578 (40.5) | 92 (30.2) | 532 (40.5) | 239 (40.4) | 385 (37.5) |
| Obstructive CAD | 9 (4.7) | 350 (24.5) | 15 (4.9) | 344 (26.2) | 56 (9.5) | 303 (29.5) |
| Prognostically significant CAD∗ | 4 (2.1) | 127 (8.9) | 6 (2.0) | 125 (9.5) | 12 (2.0) | 119 (11.6) |
| Subsequent coronary revascularization—90 days | 2 (0.4) | 249 (7.7) | 4 (0.5) | 247 (8.2) | 7 (0.5) | 244 (10.5) |
| PCI | 2 (0.4) | 217 (6.7) | 4 (0.5) | 215 (7.1) | 7 (0.5) | 212 (9.1) |
| CABG | 0 (0.0) | 33 (1.0) | 0 (0.0) | 33 (1.1) | 0 (0.0) | 33 (1.4) |
| CVD death or nonfatal MI—3 yrs | 2 (0.4) | 71 (2.2) | 4 (0.5) | 69 (2.3) | 17 (1.2) | 56 (2.4) |
Values are n or n (%).
CABG = coronary artery bypass graft; CAD = coronary artery disease; CCTA = coronary computed tomography angiography; MI = myocardial infarction; PCI = percutaneous coronary intervention; other abbreviations as in Table 1.
∗
Prognostically significant CAD was defined as 3-vessel disease, 2-vessel disease including the proximal left anterior descending artery, or obstructive disease involving the left main stem.