Figure 2.

ZSWIM5 expression is decreased in NSCLC tissues and closely related to the poor prognosis of NSCLC patients.

Notes: (A, B) ZSWIM5 exhibited moderate to strong staining in adjacent non-tumor lung tissues and was located in the cytoplasm and nucleus (200× magnification). (C, D) ZSWIM5 showed weak staining in adenocarcinoma tissues and was mainly located in the cytoplasm of cancer cells (200× magnification). (E, F) ZSWIM5 also showed weak staining in squamous cell carcinoma tissues and was located in the cytoplasm of cancer cells (200× magnification). (G–I) ZSWIM5 staining in lung cancer cells was considerably weaker than that in adjacent non-tumor lung tissue bronchial epithelial cells in the same field of view (G, 200× magnification). (J) Kaplan–Meier survival analysis shows that the decreased expression of ZSWIM5 was significantly correlated with poor prognosis of NSCLC patients (P<0.001).

Abbreviations: ZSWIM5, zinc finger SWIM-type containing 5; NSCLC, non-small-cell lung cancer.