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. 2018 Sep 4;10:3245–3254. doi: 10.2147/CMAR.S174355

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© 2018 Xu et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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siRNA interference of ZSWIM5 promotes lung cancer cell proliferation, colony formation, invasion, and migration.

Notes: (A) MTT assays showed that ZSWIM5 interference significantly promoted the proliferation abilities (the fifth day, both P<0.001) of A549 and H1299 cells. (B) Clone formation assays showed that the clone formation abilities of A549 and H1299 cells after siRNA interference were stronger (both P<0.01). (C) Transwell assays showed that siRNA treatment of ZSWIM5 promoted the invasion abilities of A549 and H1299 cells (both P<0.05). (D) Wound healing assays showed that the migration abilities of A549 and H1299 cells with knocked-down ZSWIM5 were stronger (both P<0.01). *P<0.05; **P<0.01; ***P<0.001.

Abbreviation: ZSWIM5, zinc finger SWIM-type containing 5.