Table 9.
Patient characteristics in the linked and unlinked datasets used in the Cox regression analyses
| Linked CPRD-HES n=7,063 | Unlinked CPRD n=5,197 | |
|---|---|---|
| Age, mean (SD) | 76.7 (9.5) | 76.0 (9.4) |
| Female, % | 45.9 | 42.2 |
| NVAF characteristics | ||
| NVAF duration (from first AF diagnosis to index bleed) | 24.9 (24.2) | 29.1 (24.1) |
| NVAF duration (categorized), % | ||
| <3 months, % | 19.0 | 8.4 |
| 3–6 months, % | 8.4 | 8.0 |
| 6–9 months, % | 7.1 | 7.7 |
| 9–12 months, % | 5.6 | 6.6 |
| ≥12 months, % | 59.8 | 69.3 |
| Newly diagnosed NVAF (past 12 months), % | 40.2 | 30.7 |
| Duration of available baseline period (months), mean (SD) | 465 (213) | 476 (208) |
| Duration of follow-up period in months, mean (SD) | 59.7 (40.7) | 56.0 (35.9) |
| Index bleed characteristics | ||
| Calendar year of index bleed, % | ||
| 2003–2007 | 52.3 | 59.0 |
| 2008–2012 | 47.7 | 41.0 |
| Site of initial bleed, % | ||
| Gastrointestinal | 39.5 | 29.6 |
| Respiratory | 20.2 | 23.6 |
| Urinary | 20.0 | 23.9 |
| Intracranial | 7.4 | 5.0 |
| Intraocular | 1.7 | 2.3 |
| Gynecological | 1.7 | 2.7 |
| Intraarticular | 1.4 | 1.5 |
| Gum | 0.7 | 1.2 |
| Retroperitoneal | 0.5 | 0 |
| All other bleeds | 7.0 | 10.2 |
| Major bleed, % | 17.2 | 8.3 |
| History of bleeding risk factors | ||
| Bleeding history/predisposition, % | 55.1 | 42.2 |
| Liver disease, % | 1.7 | 0.5 |
| Renal disease, % | 23.5 | 25.6 |
| Drugs predisposing to bleedinga, % | 13.2 | 18.1 |
| Modified HAS-BLED score (0–8), mean (SD) | 3.0 (1.1) | 2.6 (1.2) |
| Serum creatinine, mean (SD) | 103.7 (52.1) | 104.9 (51.3) |
| Glomerular filtration rate, mean (SD) | 0.34 (0.4) | 0.34 (0.3) |
| History of stroke risk factors | ||
| Stroke/TIA, % | 24.6 | 20.4 |
| Systemic thromboembolism, % | 1.4 | 0.7 |
| Congestive heart failure, % | 28.2 | 21.8 |
| Vascular diseases, % | 25.2 | 38.2 |
| Hypertension, % | 90.0 | 60.9 |
| Diabetes, % | 16.4 | 15.7 |
| CHAD2 score (0 to 6), mean (SD) | 2.5 (1.3) | 2.0 (1.3) |
| CHA2DS2-VASc score (0–10), mean (SD) | 4.1 (1.6) | 3.7 (1.7) |
| Other medical histories | ||
| Smoking status, % | ||
| Current | 14.3 | 15.2 |
| Past or neverb | 2.5 | 2.9 |
| Unknown | 84.2 | 83.0 |
| BMI, mean (SD) | 27.4 (5.7) | 28.1 (5.8) |
| Underweight, % | 2.2 | 1.6 |
| Normal, % | 30.5 | 20.0 |
| Obese, % | 23.5 | 21.6 |
| Overweight, % | 35.3 | 25.0 |
| Unknown, % | 8.5 | 31.8 |
| Weight, mean (SD) | 78.7 (18.4) | 81.0 (19.4) |
| Active cancer (current/prior 12 months), % | 9.6 | 4.9 |
| Falls, % | 0.1 | 0.2 |
Notes:
a
Prescriptions within 90 days prior to index bleed.
b
May overlap with current smoker.
Abbreviations: HAS-BLED, hypertension, abnormal renal and liver function, stroke, bleeding, labile INR, elderly, drugs or alcohol; HES, hospital episode statistics; CPRD, Clinical Practice Research Datalink; AF, atrial fibrillation; NVAF, non-valvular atrial fibrillation; BMI, body mass index; TIA, transient ischemic attack.