Table 1.
Numbers of all ADRs and TIN from 2004 to 2016
| Year
|
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | 2016 | |
| All ADRs | |||||||||||||
| Total number of reports | 86,287 | 109,049 | 111,224 | 120,135 | 133,760 | 127,469 | 157,672 | 184,380 | 212,583 | 160,534 | 194,853 | 211,587 | 174,589 |
| Death due to all | 6,841 | 8,296 | 8,081 | 9,128 | 10,247 | 10,133 | 10,603 | 11,397 | 10,122 | 10,130 | 13,928 | 13,557 | 11,678 |
| ADRs | (7.9%) | (7.6%) | (7.3%) | (7.6%) | (7.7%) | (7.9%) | (6.7%) | (6.2%) | (4.8%) | (6.3%) | (7.1%) | (6.4%) | (6.7%) |
| Nonrecovery from | 8,178 | 10,234 | 10,534 | 10,846 | 12,773 | 12,425 | 16,549 | 18,647 | 24,031 | 15,025 | 20,838 | 22,709 | 15,183 |
| ADRs | (9.5%) | (9.4%) | (9.5%) | (9.0%) | (9.5%) | (9.7%) | (10.5%) | (10.1%) | (11.3%) | (9.4%) | (10.7%) | (10.7%) | (8.7%) |
| TIN | |||||||||||||
| Total number of reports | 159 | 174 | 122 | 150 | 266 | 140 | 143 | 214 | 351 | 241 | 395 | 428 | 305 |
| Death due to | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 1 | 4 | 0 |
| drug-induced TIN | (0%) | (1.2%) | (0%) | (0%) | (0.4%) | (0%) | (0%) | (0.9%) | (0%) | (0%) | (0.3%) | (0.9%) | (0%) |
| Nonrecovery from | 31 | 19 | 12 | 4 | 67 | 35 | 10 | 37 | 30 | 18 | 46 | 36 | 28 |
| drug-induced TIN | (19.5%) | (10.9%) | (9.8%) | (2.7%) | (25.2%) | (25.0%) | (7.0%) | (17.3%) | (8.5%) | (7.5%) | (11.6%) | (8.4%) | (9.2%) |
Abbreviations: ADR, adverse drug reaction; TIN, tubulointerstitial nephritis.