. 2018 Jul 9;7(8):932–940. doi: 10.1530/EC-18-0141
This work is licensed under a Table 1.
Baseline data and serum FGF1 levels for the obese children and adolescents and the normal-weight healthy controls.
| Variable | Total | Obesity | ||||
|---|---|---|---|---|---|---|
| Controls (n = 44) | Obesity (n = 44) | P | Non-IR (n = 26) | IR (n = 18) | P | |
| Age (years) | 9.45 ± 0.33 | 9.51 ± 0.34 | 0.906 | 9.83 ± 0.50 | 9.05 ± 0.38 | 0.259 |
| Sex (boy:girl) | 24:20 | 21:23 | NS | 13:13 | 8:10 | NS |
| Height (cm) | 134.9 ± 1.8 | 139.7 ± 1.9 | 0.066 | 140.9 ± 3.0 | 138.1 ± 1.9 | 0.479 |
| Weight (kg) | 30.8 ± 1.1 | 46.0 ± 2.0 | 0.000 | 47.7 ± 3.0 | 43.6 ± 2.0 | 0.265 |
| BMI (kg/m2) | 16.6 ± 0.2 | 23.1 ± 0.4 | 0.000 | 23.4 ± 0.5 | 22.7 ± 0.5 | 0.389 |
| BMI z-score | 0.10 ± 0.04 | 2.42 ± 0.08 | 0.000 | 2.37 ± 0.09 | 2.47 ± 0.13 | 0.516 |
| WC (cm) | 60.0 ± 1.2 | 77.7 ± 1.9 | 0.000 | 77.9 ± 2.7 | 77.4 ± 2.6 | 0.901 |
| FG (mmol/L) | 4.78 ± 0.08 | 4.99 ± 0.06 | 0.510 | 4.92 ± 0.09 | 5.08 ± 0.08 | 0.200 |
| Fasting insulin (mIU/L) | 6.96 ± 0.29a | 13.64 ± 1.33a | 0.000 | 8.68 ± 0.64a | 20.80 ± 2.23a | 0.000 |
| HOMA-IR | 1.49 ± 0.07a | 3.03 ± 0.30a | 0.000 | 1.89 ± 0.14a | 4.67 ± 0.50a | 0.000 |
| HbA1c (%) | 4.99 ± 0.06 | 5.29 ± 0.04 | 0.000 | 5.29 ± 0.05 | 5.29 ± 0.06 | 0.996 |
| TC (mmol/L) | 4.19 ± 0.09 | 4.27 ± 0.10 | 0.548 | 4.36 ± 0.14 | 4.14 ± 0.16 | 0.320 |
| TG (mmol/L) | 1.08 ± 0.05 | 0.97 ± 0.05 | 0.101 | 0.90 ± 0.06 | 1.07 ± 0.07 | 0.078 |
| HDL-C (mmol/L) | 1.56 ± 0.05 | 1.50 ± 0.05 | 0.361 | 1.57 ± 0.06 | 1.40 ± 0.06 | 0.061 |
| LDL-C (mmol/L) | 2.26 ± 0.04 | 2.48 ± 0.07 | 0.008 | 2.50 ± 0.10 | 2.46 ± 0.10 | 0.819 |
| Apo-A (g/L) | 1.27 ± 0.04 | 1.21 ± 0.03 | 0.278 | 1.27 ± 0.05 | 1.12 ± 0.04 | 0.031 |
| Apo-B (g/L) | 0.80 ± 0.02 | 0.78 ± 0.02 | 0.375 | 0.79 ± 0.03 | 0.75 ± 0.03 | 0.360 |
| ALT (IU/L) | 16.9 ± 0.8 | 22.8 ± 2.0 | 0.000 | 18.1 ± 1.5 | 29.4 ± 4.0 | 0.000 |
| FGF1 (pg/mL) | 12.7 ± 0.2 | 30.0 ± 1.0 | 0.000 | 27.7 ± 1.0 | 33.1 ± 1.8 | 0.012 |
| NAFLD | 0 | 13 (30%) | 1 (0.04%) | 12 (66.6%) | 0.000b | |
Baseline data are given as means ± s.e.m.s.
aData not normally distributed; bchi-square analysis.
ALT, alanine aminotransferase; Apo-A, apolipoprotein A; Apo-B, apolipoprotein B; FG, fasting glucose; FGF1, fibroblast growth factor 1; HbA1c, hemoglobin A1c; HDL-C, high-density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance; IR, insulin-resistant; LDL-C, low-density lipoprotein cholesterol; NAFLD, non-alcoholic fatty liver disease; NS, not significant; TC, total cholesterol; TG, triglyceride; WC, waist circumferences.