Table 3.

Baseline data and serum FGF1 levels for the obese children and adolescents after 6 months of lifestyle intervention (n = 39, boys:girls = 18:21).

Variables	Before	After	Changes	Pb
Age (years)	9.41 ± 0.37	9.91 ± 0.37	0.5
Height (cm)	139.0 ± 2.1	140.9 ± 2.1	2.0 ± 0.1	<0.001
Weight (kg)	45.2 ± 2.1a	42.8 ± 2.0a	2.3 ± 0.1a	<0.001
BMI (kg/m2)	22.9 ± 0.4	21.1 ± 0.4	1.8 ± 0.1	<0.001
BMI z-score	2.41 ± 0.08	1.73 ± 0.07	0.68 ± 0.02	<0.001
WC (cm)	76.3 ± 1.9	75.0 ± 1.9	1.3 ± 0.1	<0.001
FG (mmol/L)	4.97 ± 0.07	4.89 ± 0.07	0.07 ± 0.01	<0.001
Fasting insulin (mIU/L)	11.39 ± 0.85a	8.66 ± 0.68a	2.73 ± 0.28	<0.001
HOMA-IR	2.51 ± 0.19a	1.89 ±0.15a	0.63 ± 0.06	<0.001
HbA1c (%)	5.27 ± 0.04	4.97 ± 0.03	0.30 ± 0.02a	<0.001
TC (mmol/L)	4.29 ± 0.12	3.72 ± 0.08	0.57 ± 0.05	<0.001
TG (mmol/L)	0.98 ± 0.05	0.89 ± 0.04	0.09 ± 0.01	<0.001
HDL-C (mmol/L)	1.52 ± 0.05	1.55 ± 0.05	0.02 ± 0.01	<0.001
LDL-C (mmol/L)	2.47 ± 0.08	2.37 ± 0.07	0.10 ± 0.01	<0.001
Apo-A (g/L)	1.22 ± 0.04	1.16 ± 0.04	0.06 ± 0.01	<0.001
Apo-B (g/L)	0.78 ± 0.02	0.69 ± 0.02	0.09 ± 0.01	<0.001
ALT (IU/L)	22.5±2.2a	19.7 ± 1.7a	2.9 ± 0.5a	<0.001
FGF1 (pg/mL)	29.4 ±1.0	22.2 ± 0.7	7.2 ± 0.4	<0.001

Baseline data are given as means ± s.e.m.s.

^aData not normally distributed; ^bpaired samples t-test. t-test for the age variable cannot be computed because the s.e.m. of the difference is zero.

ALT, alanine aminotransferase; Apo-A, apolipoprotein A; Apo-B, apolipoprotein B; FG, fasting glucose; FGF1, fibroblast growth factor 1; HbA1c, hemoglobin A1c; HDL-C, high-density lipoprotein cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglyceride; WC, waist circumferences.