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Differentially expressed signaling genes in IL18KO/APP/PS1 mice. (A) Results of qPCR to detect increased NPY mRNA in hippocampi of IL18KO/APP/PS1 mice (n = 8–12 per group, ANOVA test, *P < 0.05, **P < 0.01). (B–E) qPCR detecting somatostatin receptor 2 (Sstr2), proenkephalins (Penk), galanin, and tryptophan 2,3-dioxygenase (Tdo2) mRNAs in hippocampi from IL18KO/APP/PS1 mice (n = 8–12 per group, ANOVA test, *P < 0.05, **P < 0.01).
