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IDH1-mutated diffuse astrocytomas shows local disease progression. (A) This representative patient with diffuse astrocytoma illustrates disease progression adjacent to the initial lesion. (B) Retrospective analysis of 130 patients with IDH-mutated diffuse astrocytomas reveals local progression within 2 cm of the initial lesion in 81.8% of patients. (C) Median progression-free survival was 4.7 y for local failure vs. 5.1 y for distal failure.
