Fig. 3.

The SNP classes most common in regions affected by TAM are also most common at tRNA loci. Shown is the distribution of each class of low-frequency polymorphisms by region across all human tRNAs. Stars indicate the significance levels of Fisher’s exact tests comparing the SNP distribution within each region of the tRNA and flank (outer 5′ flank in yellow, inner 5′ flank in orange, tRNA in purple, inner 3′ flank in cyan, outer 3′ flank in blue) with that of the untranscribed reference region (black): one star, P ≤ 0.05; two stars, P ≤ 0.005; and three stars, P ≤0.0005.