Table 3.

Pharmacokinetic parameters of celastrol in rats after oral administration of celastrol (1 mg/kg; n = 6, mean ± SD) with or without diclofenac (10 mg/kg).

Parameter	Control	Treatment with diclofenac
Tmax (h)	6.05 ± 1.12	7.68 ± 1.15
Cmax (μg/L)	66.93 ± 10.28	41.25 ± 8.06*
t1/2 (h)	7.82 ± 1.31	5.93 ± 1.27
AUC(0-t) (μg × h/L)	765.84 ± 163.61	451.33 ± 110.88*
AUC(0-∞) (μg × h/L)	804.60 ± 190.11	462.30 ± 120.71*
λ (h−1)	0.09 ± 0.02	0.12 ± 0.03
Oral CL (L/h/kg)	1.29 ± 0.15	2.27 ± 0.31*

^*p < 0.05 indicates significant differences from the control.