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Electron-density maps near the M20 loop, NADP+ and FOL of the M20-open crystal at (a) 0.1, (b) 270, (c) 500 and (d) 750 MPa. The nicotinamide moiety of NADP+ is flipped out at 500 MPa, but the electron densities of the M20 loop and FOL are still evident at 750 MPa. The electron-density map covers key structures and is shown at 1.0σ. The structures in (a) and (b) are of the B chain.
