Table 1.
Chemical structure of piplartine (1) and cinnamides (2–5), and concentrations able to inhibit 50% of the cells (IC50), L. amazonensis, P. falciparum and peritoneal cells of Swiss mice.
| Selectivity Index (SI) = CC50/ IC50 |
|||||
|---|---|---|---|---|---|
| Estimated IC50: μM (μg/mL) |
Estimated CC50: μM (μg/mL) |
||||
|
L. amazonensis |
P. falciparum |
Peritoneal cell |
|||
| Compounds | Chemical structure Molar Mass (g/mol) | 6 h | 48 h | 72 h | 6 h |
| 1 |
 317.34 |
564.1 (179.0) SI = 1.3 |
19.5 (6.2) SI = 37.4a |
10.1 (3.2) SI = 72.5a |
731.1 (232.0) |
| 2 |
 307.34 |
1,099.7 (338.0) SI = 0.7 |
325.4 (100.0) SI = 2.6 |
126.9 (39.0) SI = 6.8 |
868.7 (267.0) |
| 3 |
 277.32 |
2,141.9 (594.0) SI = 0.4 |
334.9 (92.9) SI = 2.9 |
623.8 (173.0) SI = 1.5 |
988.2 (274.0) |
| 4 |
 307.38 |
1,411.9 (434.0) SI = 1.0 |
79.1 (24.3) SI = 18.3a |
134.7 (41.4) SI = 10.7a |
1,447.7 (445.0) |
| 5 |
 277.36 |
382.2 (106.0) SI = 2.4 |
101.7 (28.2) SI = 9.0 |
23.8 (6.6) SI = 38.4a |
915.8 (254.0) |
a
Compounds potentially microbicides and safe for the host cells, once the SI was greater than 10.