Table 2.
Prognostic values of MCM genes expression in PDAC OS of TCGA cohort
| Gene expression | Events/total (n=112) | MST (days) | Crude HR (95% CI) | Crude P-value | Adjusted HR (95% CI) | Adjusted P-valuea |
|---|---|---|---|---|---|---|
| MCM2 | ||||||
| Low | 31/56 | 592 | 1 | 1 | ||
| High | 38/56 | 498 | 1.345 (0.828–2.185) | 0.230 | 1.614 (0.929–2.805) | 0.089 |
| MCM3 | ||||||
| Low | 33/56 | 592 | 1 | 1 | ||
| High | 36/56 | 517 | 1.096 (0.679–1.769) | 0.708 | 0.773 (0.453–1.320) | 0.346 |
| MCM4 | ||||||
| Low | 28/56 | 634 | 1 | 1 | ||
| High | 41/56 | 458 | 1.990 (1.210–3.272) | 0.007 | 2.409 (1.351–4.294) | 0.003 |
| MCM5 | ||||||
| Low | 32/56 | 607 | 1 | 1 | ||
| High | 37/56 | 393 | 1.692 (1.041–2.749) | 0.034 | 1.185 (0.693–2.028) | 0.535 |
| MCM6 | ||||||
| Low | 33/56 | 511 | 1 | 1 | ||
| High | 36/56 | 568 | 0.867 (0.534–1.408) | 0.564 | 1.104 (0.645–1.889) | 0.718 |
| MCM7 | ||||||
| Low | 31/56 | 603 | 1 | 1 | ||
| High | 38/56 | 485 | 1.456 (0.897–2.364) | 0.129 | 1.183 (0.660–2.119) | 0.572 |
Note:
a
Adjusted for histologic grade, radiation therapy, radical resection, and targeted molecular therapy.
Abbreviations: MCM, minichromosome maintenance; MST, median survival time; OS, overall survival; PDAC, pancreatic ductal adenocarcinoma; TCGA, The Cancer Genome Atlas.