Table 3.

Joint effects survival analysis of clinical factors and the MCM4 expression with OS in PDAC patients

Group	MCM4	Variables	Events/total (n=112)	MST (days)	Crude HR (95% CI)	Crude P-value	Adjusted HR (95% CI)	Adjusted P-valuea
Histologic grade
A	Low expression	G1 + G2	20/44	634	1		1
B	Low expression	G3 + G4	8/12	592	1.652 (0.711–3.837)	0.243	1.782 (0.713–4.457)	0.217
C	High expression	G1 + G2	25/36	518	1.830 (0.991–3.380)	0.054	2.146 (1.051–4.383)	0.036
D	High expression	G3 + G4	16/20	278	3.788 (1.893–7.579)	<0.001	5.185 (2.373–11.329)	<0.001
Radiation therapyb
a	Low expression	No	17/31	607	1		1
b	Low expression	Yes	8/19	702	0.686 (0.289–1.626)	0.392	1.403 (0.513–3.836)	0.510
c	High expression	No	31/39	366	2.047 (1.097–3.819)	0.024	2.977 (1.509–5.871)	0.002
d	High expression	Yes	7/11	627	1.010 (0.408–2.497)	0.983	0.657 (1.880–5.378)	0.239
Radical resectionc
I	Low expression	R0	20/41	702	1		1
II	Low expression	R1/Rx	7/13	592	1.732 (0.708–4.232)	0.229	1.457 (0.555–3.826)	0.445
III	High expression	R0	19/25	517	1.775 (0.924–3.408)	0.085	2.413 (1.162–5.014)	0.018
IV	High expression	R1/Rx	22/31	308	2.975 (1.560–5.673)	0.001	3.498 (1.724–7.101)	0.01
Targeted molecular therapyd
i	Low expression	No	8/13	467	1		1
ii	Low expression	Yes	18/37	702	0.239 (0.098–0.583)	0.002	0.204 (0.076–0.547)	0.002
iii	High expression	No	16/16	145	5.036 (2.007–12.638)	0.001	4.303 (1.625–11.399)	0.003
iv	High expression	Yes	23/36	603	0.411 (0.180–0.940)	0.035	0.357 (0.148–0.859)	0.021

Notes:

^aAdjusted for histologic grade, radiation therapy, radical resection, and targeted molecular therapy.

^bRadiation therapy information is unavailable in 12 patients;

^cradical resection information is unavailable in two patients.

^dTargeted molecular therapy information is unavailable in 10 patients.

Abbreviations: HR, hazard ratio; MST, median survival time; OS, overall survival; PDAC, pancreatic ductal adenocarcinoma.