Table 4.
Effect of S. platensis on serum oxidative stress and liver function levels.
| Parameters | G1:NC | G2:DC | G3:SPC | G4:D + Met | G5:D + Met | G6:MetC |
|---|---|---|---|---|---|---|
| Oxidative stress | ||||||
| TAS [mmol/L] | 1.08 ± 0.05 | 0.46 ± 0.07‡ | 1.32 ± 0.043 | 0.58 ± 0.08* | 0.81 ± 0.11** | 1.17 ± 0.065 |
| SOD [U/mL] | 62.06 ± 5.20 | 30.12 ± 6.35‡ | 80.3 ± 4.12 | 40.41 ± 6.5** | 57.85 ± 8.2*** | 69.40 ± 5.00 |
| Gpx [U/mL] | 8.56 ± 0.62 | 4.11 ± 1.70‡ | 9.43 ± 0.83 | 5.31 ± 1.20*** | 6.52 ± 1.44*** | 8.91 ± 0.43 |
| GRx [U/g protein] | 24.32 ± 2.11 | 17.84 ± 4.11‡ | 26.52 ± 2.05 | 18.44 ± 3.13 | 21.17 ± 3.63** | 25.81 ± 2.21 |
| TBARS [mmol/g protein] | 23.92 ± 2.34 | 50.17 ± 6.54‡ | 21.91 ± 2.21 | 47.56 ± 4.70 | 31.63 ± 5.7*** | 22.37 ± 2.51 |
| Liver function [UI/L] | ||||||
| AST 60d | 94.95 ± 4.56 | 141.04 ± 6.73 | 74.34 ± 7.98 | 123.56 ± 8.62 | 112.05 ± 5.53 | 84.90 ± 5.95 |
| 70d | 95.10 ± 4.43 | 140.91 ± 8.24*** | 72.63 ± 6.48 | 141.56 ± 6.21c | 105.36 ± 5.84‡ | 87.66 ± 7.84 |
| ALT 60d | 53.00 ± 9.14 | 80.43 ± 11.96 | 47.74 ± 8.64 | 70.20 ± 12.86 | 58.50 ± 9.20 | 56.24 ± 8.78 |
| 70d | 53.60 ± 7.26 | 78.75 ± 12.90*** | 46.80 ± 7.74 | 82.11 ± 14.88b | 50.33 ± 9.40‡b | 57.08 ± 7.14 |
| Alk-p 60d | 66.69 ± 5.51 | 103.02 ± 11.74 | 47.12 ± 7.30 | 94.60 ± 14.64 | 85.56 ± 12.86 | 66.80 ± 9.42 |
| 70d | 68.01 ± 5.10 | 99.36 ± 13.70*** | 46.26 ± 8.28 | 100.18 ± 12.46 | 79.64 ± 11.54‡b | 67.40 ± 12.24 |
NC: Normal Control; DC: Diabetic Control; SPC: SP control; D + Met: Diabetic rats treated with metformin; D + SP: Diabetic rats treated with SP; MetC: Metformin control. Each value represents mean ± SE (n = 8).Oxidative stress (‡p < 0.001, compared with group 1 values,*p < 0.05; **p < 0.01, *** p < 0.001 compared with group 2 values at the end of experiment). Liver function (**p < 0.01, compared with group 1 values, ***p < 0.001, compared with group 1 values, †p < 0.01, compared with group 2 values, ‡p < 0.001, compared with group 2 values at the end of experiment, (a) p < 0.05, (b) p < 0.01, (c) p < 0.001, compared the same group before and after arrest of treatment (60th and 70th day) values).