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. 2017 Dec 8;56(1):1–11. doi: 10.1080/13880209.2017.1412467

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — IRhom2/TACE involved in secretion of TNFα in kidney intrinsic cells. (A) The expression of TACE in HRMC, HK-2, BMDM and splenocytes analysed by real-time PCR; (B) the expression of iRhom2 in HRMC, HK-2, BMDM and splenocytes analysed by real-time PCR; (C) western blotting analysis of the expression of TACE in HRMC, HK-2, BMDM and splenocytes, pro: pro-TACE, mat: mature TACE; (D) western blotting analysis knockdown efficiency of two siRNA of iRhom2 in HK-2 cells; (E) western blotting analysis protein level of TACE in HK-2 cells when iRhom2 was knockdown, pro: pro-TACE, mat: mature TACE; (F) the activity of TACE in HK-2 was measured when iRhom2 was knockdown, **p < 0.01, n = 3, compared with control; (G) the secretion of TNFα in HK-2 was inhibited when iRhom2 was knockdown by siRNA, **p < 0.01, n = 3, compared with control.