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. 2017 Dec 8;56(1):1–11. doi: 10.1080/13880209.2017.1412467

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Effects of TFA on the formation of glomerulosclerosis fibrosis in the renal tissues of STZ-induced DN rats. (A) Representative periodic acid-Schiff staining of paraformaldehyde-fixed kidney sections from the rats of each group (n = 10 rats/group): non-DN, DN + vehicle, DN + PBA, DN + low dose (LD)-TFA, DN + middle dose (MD)-TFA and DN + high dose (HD)-TFA; (B) glomerular changes were evaluated by total number of cells per glomerular cross-section (GCS); (C) glomerular injury was detected by relative area of extracellular matrix (ECM), magnification, 400×. The data are expressed as mean ± SD. *p < 0.05 vs. non-DN, ^#p < 0.05 vs. DN + vehicle; (D) semi-quantitative analyses of glomerulosclerosis index (GSI) in DN rats with or without TFA treatment, the data are expressed as mean ± SD. *p < 0.05 vs. non-DN, ^#p < 0.05 vs. DN + vehicle.