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. 2017 Dec 8;56(1):1–11. doi: 10.1080/13880209.2017.1412467

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — TFA attenuates inflammatory processes and inhibits activation of iRhom2/TACE signalling in DN rats. (A) TFA decreased expression of inflammatory cytokine genes in renal tissues of DN rats, *p < 0.05 vs. non-DN, ^#p < 0.05 vs. DN + vehicle, n = 10; (B) TFA inhibited the activity of TACE in renal tissues of DN rats, *p < 0.05 vs. non-DN, ^#p < 0.05 vs. DN + vehicle, n = 10; (C) western blotting analysis of the activation of iRhom2/TACE signalling, the activation of TNFα and the expression of ER stress markers XBP1S and GPR94 in renal tissues of DN rats.