Table 2.
The nine PPARγ agonists with known agonistic activity.
| Agonistic activity |
||||
|---|---|---|---|---|
| Agonist | Molecular structure | Docking score (kcal/mol) | EC50 (nM) | pEC50 |
| Pioglitazone |  |
−8.69 | 280 (Xu et al. 2001) | 6.55 |
| Rosiglitazone |  |
−9.34 | 18 (Xu et al. 2001) | 7.74 |
| Farglitazar |  |
−7.78 | 0.20 (Xu et al. 2001) | 9.70 |
| GW409544 |  |
−7.20 | 0.28 (Xu et al. 2001) | 9.55 |
| Troglitazone |  |
−6.52 | 550 (Willson et al. 2000) | 6.26 |
| Ciglitazone |  |
−5.43 | 3000 (Willson et al. 1996) | 5.52 |
| E3030 |  |
−8.26 | 34 (Kasai et al. 2008) | 7.47 |
| CLX-0921 |  |
−7.34 | 284 (Dey et al. 2003) | 6.55 |
| EXP3179 |  |
−5.23 | 17,000 (Schupp et al. 2006) | 4.77 |