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. 2018 Mar 22;56(1):235–244. doi: 10.1080/13880209.2018.1448873

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Treatment of MCF-7 (ER+) cells with 2 at the IC₅₀ for 24 h decreased the expression of Bcl-2, the anti-apoptosis gene and increased the Bax/Bcl-2 ratio to ∼3.5 indicating that the extract induces apoptosis in MCF-7 cells via the intrinsic pathway. Control MCF-7 cells were treated with vehicle solvent only. For Bcl2 mRNA p < 0.001 MCF-7 vs. control; for the Bax/Bcl2 ratio p < 0.001 MCF-7 vs. control.