Table 2.

Effect of CEL and its combination with FA on the Tn-T and TNF-α levels.

Group	Treatment	Tn-T (pg/ml)	TNF-α (pg/ml)
I	CONTROL	10.89 ± 0.94	0.044 ± 0.01
II	DOX	196.09 ± 26.58***	1740.91 ± 148.68***
III	CEL	138.27 ± 11.92†††	1109.67 ± 91.71†††
IV	CEL + DOX	389.77 ± 70.11###	2743.78 ± 188.27###
V	FA	9.57 ± 0.81	0.042 ± 0.01
VI	CEL + FA	68.17 ± 12.08**	683.86 ± 115.47§§§
VII	CEL + FA + DOX	204.55 ± 18.71‡‡‡	1892.41 ± 244.61‡‡‡

Values are expressed as the mean ± SD and analyzed by one-way ANOVA followed by the Tukey–Kramer multiple comparison test.

^**p < 0.01 (VI vs. III).

^***p < 0.001 (II vs. I).

^†††p < 0.001(III vs. I).

^###p < 0.001 (IV vs. II).

^§§§p < 0.001 (VI vs. III), and

^‡‡‡p < 0.001 (VII vs. IV).

CEL: Celecoxib; FA: Folic acid; DOX: Doxorubicin.