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. 2016 Dec 7;55(1):269–276. doi: 10.1080/13880209.2016.1260598

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© 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/Licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Effect of SD17 treatment on plasma and peritoneal lavage fluid (PLF) concentrations of IL-1β and IL-6 at 4, 6 and 24 h after Sham or CLP surgery. Concentration of (A) IL-1β and (C) IL-6 in plasma and (B) IL-1β, and (D) IL-6 the PLF animals subjected to sham operation (Sham) or sepsis induced by caecal ligation and puncture (CLP), pretreated and treated by gavage with SD17 (100 mg/kg) or vehicle (water). The values shown are means ± SEM. *p < 0.001 compared to the Sham group; +p < 0.001 compared to the same group; #p < 0.05 compared to vehicle (water) treatment in the same period and same group. n = 4–11 animals/group. ND: not detectable.