Table 3.
In vitro cytotoxic activity of triterpenes isolated from aerial parts of T. alternans collected in Nová Sedlica, Slovakia. Cells (5–8 × 104·mL − 1) were treated for 72 h with increasing concentrations of tested compounds.
| IC50(μM) ± S.D. | |||||
|---|---|---|---|---|---|
| Compound | A375 | HCT-15 | A431 | BxPC3 | U1810 |
| T1 | 1.57 ± 0.72 | 0.88 ± 0.22 | 4.54 ± 1.06 | 0.52 ± 0.24 | 2.86 ± 0.83 |
| T2 | 1.26 ± 0.12 | 1.46 ± 0.13 | 4.98 ± 1.14 | 1.84 ± 0.31 | 2.25 ± 1.05 |
| T3 | 0.48 ± 0.67 | 0.67 ± 0.09 | 2.03 ± 0.98 | 0.42 ± 0.13 | 0.98 ± 0.21 |
| T4 | 1.45 ± 0.56 | 1.69 ± 0.72 | 4.85 ± 1.32 | 1.42 ± 0.73 | 3.59 ± 1.31 |
| T5 | 0.87 ± 0.32 | 2.42 ± 1.05 | 3.28 ± 1.09 | 1.84 ± 0.91 | 2.93 ± 1.13 |
| T6 | 0.45 ± 0.10 | 0.54 ± 0.08 | 2.16 ± 0.83 | 0.19 ± 0.09 | 1.62 ± 0.85 |
| Betulinic acid | ND | 6.85 ± 2.18 | 8.96 ± 2.83 | 4.28 ± 1.35 | ND |
| Cisplatin | 2.06 ± 1.01 | 15.53 ± 2.48 | 1.96 ± 0.84 | 10.17 ± 1.65 | 0.76 ± 0.85 |
S.D. = standard deviation. ND = not detected. Cell viability was evaluated by means of MTT test. IC50 values were calculated by the dose–response curves by means of four parameter logistic model (p < 0.05).