Table 1.
Effect of 10 days daily oral administration of N-acetylcysteine and saponin on hepatocyte integrity loss markers in rats with ferrous sulphate-induced hepatotoxicity.
| Parameters | ALT (U/L) | AST (U/L) | ALP (U/L) | GGT (U/L) | LDH (U/L) |
|---|---|---|---|---|---|
| Statistical data | (F = 74.24, dF between groups =3, dF within groups =27) | (F = 146.80, dF between groups =3, dF within groups =28) | (F = 89.86, dF between groups =3, dF within groups =22) | (F = 63.59, dF between groups =3, dF within groups =28) | (F = 97.36, dF between groups =3, dF within groups =23) |
| Normal control (2% Tween 80, p.o.) | 23.9 ± 0.80 (n = 8) | 52.5 ± 1.37 (n = 8) | 76.1 ± 5.27 (n = 6) | 10.9 ± 0.97 (n = 8) | 317.2 ± 8.85 (n = 7) |
| Hepatotoxicity control (FeSO4, 30 mg/kg for 2 days, i.p.) | 60.8 ± 2.38a (n = 8) | 124.8 ± 3.24a (n = 8) | 351.5 ± 10.67a (n = 7) | 58.8 ± 3.75a (n = 8) | 1098.0 ± 47.53a (n = 8) |
| N-acetylcysteine + Ferrous sulphate | 31.4 ± 1.91ab (n = 8) | 73.4 ± 2.91ab (n = 8) | 162.5 ± 14.30ab (n = 7) | 29.4 ± 2.26ab (n = 8) | 561.7 ± 33.90ab (n = 6) |
| Saponin + Ferrous sulphate | 34.4 ± 2.15ab (n = 7) | 82.8 ± 2.10ab (n = 8) | 267.9 ± 17.12abc (n = 6) | 35.3 ± 2.11ab (n = 8) | 598.1 ± 30.27ab (n = 6) |
aSignificantly different from normal control group at p < 0.05.
bSignificantly different from hepatotoxicity control group at p < 0.05.
cSignificantly different from N-acetylcysteine control group at p < 0.05.