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. 2017 May 3;55(1):1703–1709. doi: 10.3109/13880209.2015.1045621

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Inhibition of UGT1A9-mediated 4-MU glucuronidation reaction by cryptotanshinone. (A) Dixon plot of inhibitory effects of cryptotanshinone towards recombinant UGT1A9-catalyzed 4-MU glucuronidation. (B) Lineweaver–Burk plot of inhibitory effects of cryptotanshinone towards recombinant UGT1A9-catalyzed 4-MU glucuronidation. (C) Second plot of slopes from Lineweaver–Burk plot versus cryptotanshinone concentrations. Every data point represents the mean of two replicates.