Table 1. Initial screening of the inhibitory effects of danshen's major components towards UGTs. The values are given as mean plus SD (n = 3).
Tanshinone I | Tanshinone IIA | Cryptotanshinone | Dihydrotanshinone I | |
---|---|---|---|---|
UGT1A1 | 77.2 ± 2.8 | 69.8 ± 1.3 | 43.5 ± 1.2 | 67.3 ± 17.5 |
UGT1A3 | 68.2 ± 3.4 | 46.7 ± 1.6 | 22.2 ± 0.0 | 38.5 ± 0.4 |
UGT1A6 | 42.7 ± 0.5 | 38.7 ± 14.2 | 13.7 ± 3.4 | 38.9 ± 0.4 |
UGT1A7 | 25.8 ± 2.2 | 24.9 ± 2.4 | 7.2 ± 0.7 | 22.5 ± 9.3 |
UGT1A8 | 97.5 ± 1.7 | 79.7 ± 3.0 | 33.1 ± 7.6 | 52.1 ± 0.4 |
UGT1A9 | 29.9 ± 0.6 | 14.7 ± 3.1 | 4.9 ± 0.3 | 8.0 ± 0.0 |
UGT1A10 | 74.6 ± 2.2 | 56.8 ± 1.6 | 13.3 ± 4.8 | 37.2 ± 0.0 |
UGT2B7 | 67.6 ± 2.9 | 58.3 ± 0.2 | 12.8 ± 0.5 | 44.1 ± 6.6 |
UGT2B15 | 58.1 ± 0.8 | 65.6 ± 5.2 | 14.0 ± 0.5 | 28.6 ± 0.4 |