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. 2017 Jan 6;55(1):740–748. doi: 10.1080/13880209.2016.1275705

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Liver of rat treated with (A) indomethacin showing cytoplasmic vacuolation of hepatocytes (small arrow), small focal hepatic necrosis associated with inflammatory cells infiltration (large arrow) and Kupffer cells activation (arrow head). (B) Indomethacin showing cytoplasmic vacuolation of hepatocytes (small arrow) and sinusoidal leukocytosis (large arrow). (C) BCO showing cytoplasmic vacuolization of hepatocytes (arrows) and Kupffer cells activation (large arrow). (D) COO showing Kupffer cells activation (small arrow) and sinusoidal leukocytosis (large arrow). (E) CLO showing slight activation of Kupffer cells (arrow). (F) Control showing the normal histological structure of hepatic lobule. (H & E x 400).