Table 1.
Effect of oral administration of indomethacin and CPO on paw volume and ulcerogenicity (4 h post-injection of carrageenan-induced rat paw edema) in the adult female albino rats.
| Paw volume |
Ulcerogenic effect |
||||||
|---|---|---|---|---|---|---|---|
| Group and doses | % Baseline value | Number of animals | Number of animals showing ulcer | Mean No of ulcer | Severity of ulcer | % incidence of ulcer/10 | Ulcer index |
| Normal (100 μL Saline) | 100 | 8 | 0 | 0 | 0 | 0 | 0 |
| Carrageenan (100 μL, 1%) | 147.6*b ± 2.56 | 0 | 0 | 0 | 0 | 0 | 0 |
| Indomethacin (10 mg/kg PO) | 115.7a ± 4.14 | 8 | 6 | 6.9 ± 0.7 | 2.5 ± 0.33 | 10 | 19.4* |
| BCO (400 mg/kg PO) | 137.8*b ± 8.21 | 8 | 0 | 0 | 0 | 0 | 0 |
| COO (400 mg/kg PO) | 138.8*b ± 4.79 | 8 | 0 | 0 | 0 | 0 | 0 |
| CLO (400 mg/kg PO) | 120.2a ± 0.92 | 8 | 0 | 0 | 0 | 0 | 0 |
Data are shown as mean ± S.E.M. (n = 8).
*
Significantly different from normal value (p < 0.05).
a
Significantly different from carrageenan-treated group (p < 0.05).
b
Significantly different from indomethacin-treated group (p < 0.05).