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. 2017 Mar 6;55(1):1263–1273. doi: 10.1080/13880209.2017.1297838

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Curcumin inhibits miR-155, TNF-α and IL-6 through PI3K-AKT pathway. (A,B) Western blot analysis of PI3K p85α, p-p85α, AKT and the phosphorylation of AKT. Cells were pretreated with curcumin (5, 10, 15 μM) for 2 h, followed by stimulation with LPS for 30 min. Bands were quantified by Image J software. (C,D) Raw264.7 cells were pretreated with or without the inhibitor of PI3K (LY294002) for different time periods (0, 2, 4, 6, 8 h) before LPS stimulation for 4 h. MiR-155 (C) and mRNA levels of TNF-α and IL-6 (D) were assayed. (E,F) Western blot analysis of PI3K p85α, p-p85α, AKT, P-AKT. Raw264.7 cells were pretreated with or without LY294002 2 h followed by stimulation with LPS for 0, 15, 30, 60 min. The data are presented as the mean ± SEM of at least three independent experiments.