Table 2.
Effect of ESBCI and ESCI on paw volume of Freund’s adjuvant induced arthritic rats.
| Paw volume of the rats in ml Mean ± SEM (% inhibition) |
|||||
|---|---|---|---|---|---|
| Groups | Day 0 | Day 7 | Day 14 | Day 21 | Day 28 |
| Group I | 0.92 ± 0.010 | 0.93 ± 0.006 | 0.95 ± 0.004 | 0.93 ± 0.006 | 0.94 ± 0.007 |
| Group II | 0.98 ± 0.004 | 1.44 ± 0.013 | 1.61 ± 0.006 | 1.56 ± 0.007 | 1.54 ± 0.006 |
| Group III | 0.90 ± 0.103 (8.16%) |
1.29 ± 0.009 b* (10.42%) | 1.21 ± 0.008 b* (25.31%) | 1.15 ± 0.013 b* (26.28%) |
0.87 ± 0.006 b* (43.51%) |
| Group IV | 0.97 ± 0.003 (1.02%) |
1.27 ± 0.008 b*c* (11.80%) |
1.26 ± 0.007 b*c* (21.73%) |
1.19 ± 0.003 b*c*(23.72%) | 1.10 ± 0.009 b*c* (28.57%) |
| Group V | 0.94 ± 0.009 (4.08%) |
1.32 ± 0.005 b*c* (8.82%) |
1.28 ± 0.007 b*c* (20.49%) |
1.22 ± 0.007 b*c* (21.15%) |
0.98 ± 0.007 b*c* (36.36%) |
| Group VI | 0.94 ± 0.004 (4.08%) |
1.27 ± 0.005 b*c* (11.80%) |
1.24 ± 0.004 b*c* (22.98%) |
1.21 ± 0.003 b*c* (22.24%) |
1.13 ± 0.003 b*c* (26.62%) |
| Group VII | 0.91 ± 0.003 (7.14%) |
1.25 ± 0.003 b*c* (13.19%) |
1.22 ± 0.004 b*c* (24.22%) |
1.19 ± 0.003 b*c* (23.72%) |
1.04 ± 0.042 b*c* (32.48%) |
Group I: Normal control; Group II: Negative control; Group III: Positive control; Group IV: ESBCI (28 days drug treatment); Group V: ESCI (28 days drug treatment); Group VI: ESBCI (14 days drug treatment); Group VII: ESCI (14 days drug treatment).
Values in parenthesis indicate the percentage inhibition of paw oedema for the respective groups. Values are expressed as Mean ± SEM, n = 6 animals in each group.
Comparisons were made between: b: Group II vs. groups III, IV, V, VI and VII; c: Group III vs. groups IV, V, VI and VII.
*
Represents the statistical significance at p < .01.