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. 2016 Dec 9;55(1):560–570. doi: 10.1080/13880209.2016.1263869

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© 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Effect of total glycosides from P. hookeri on pain threshold in adjuvant-induced arthritis rats. Arthritis was induced by intradermal injection of 0.1 mL of complete Freund’s adjuvant (CFA). Total glycosides (14, 28 and 56 mg/kg) or nimesulide (33.33 mg/kg) or vehicle was administered 1 h after CFA injection and their daily treatment continued until 30 days after CFA challenge. The pain threshold (pressure pain, g) was assessed on 7, 14, 21 and 30 days after CFA injection via algesimeter. All data are represented as mean ± SD, n = 10, *p < 0.05, **p < 0.01 vs control.