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. Author manuscript; available in PMC: 2019 Feb 13.
Published in final edited form as: Nat Struct Mol Biol. 2018 Aug 13;25(9):778–786. doi: 10.1038/s41594-018-0106-9

Figure 2. The terminal uridylyltransferase CDE-1 restricts viral infection.

Figure 2

a, Diagram of cde-1 alleles. DAD, catalytic dead mutant.

b, Neighbor joining tree of the terminal uridylyl transferases (TUTs) of C. elegans and humans and S. pombe CID1.

c, Diagrams of C. elegans CDE-1 and human TUT4 and TUT7. Domains were predicted by Interpro. The central D of the conserved DDD catalytic triad is highlighted in red.

d, Viral load as measured by qRT-PCR of OrV RNA1 genome in adults two days after infection. Boxplots: whiskers from minimum to maximum; dots: independent infection; n=5. One-tailed student’s t-test: **** p<0.0001, **p<0.01