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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Circ Cardiovasc Imaging. 2018 Aug 20;11(8):e007303. doi: 10.1161/CIRCIMAGING.117.007303

Figure 7. Histological analyses show accumulation of tropoelastin in rabbit rupture-prone compared with stable plaque.

Figure 7

A, D, G, Van Gieson elastin staining (dark purple indicates elastin fibers) shows the presence of organized elastin fibers in the media of control tissue and a net accumulation of elastin fibers in the intima of stable and rupture-prone plaque. B-C, E-F, H-I, Corresponding immunohistochemistry for tropoelastin (brown staining) shows lack of tropoelastin positive fibers in control aortas, upregulation in stable and deposition of a dense network of tropoelastin fibers in rupture-prone plaque. J-K, Quantification of total elastin and tropoelastin shows significantly higher tropoelastin in ruptured compared with stable plaque.