Fig 5. Virion capture by V2 mAbs and α₄β₇ coated nanoparticles.

A) Capture of 92TH023 by MNPs coated with gp120 mAbs including 2G12 (positive control) and V2 mAbs PG9, CH58 and 830A. A non-specific Ig was employed as a negative control. Virion capture was determined by detection of MNP-bound p24 (Y-axis). Results from three independent experiments are shown. B) 92TH023 virion capture by α₄β₇-MNPs in the absence or presence of increasing concentrations of ELN-475772. Results from three independent experiments are shown. Detection of MNP -captured virus as in panel A. Error bars indicate SEM. Significance measure by ANOVA followed by the Tukey multiple comparison test (***p <0.001 and ****p <0.0001).