Figure 9.

Schematic diagram depicting the binding sites of a cobalt complex with a collagen fibril, not to scale. (A) Cobalt complex interacting with the collagen fibril directly. (B) Cobalt complex interacting with the nonfreezing water layer surrounding the collagen fibril. Proposed binding sites of a cobalt complex with a collagen fibril where interactions occur with the carboxylic group (C), hydroxyl group (D), forming a water bridge (E), or interactions with the hydroxyl structure in the carboxylic terminal (F).