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Time course of formation of Aβ40 assemblies on GM1-enriched membranes. A and B, raw (blue lines) and second-derivative (red lines) reflection–absorption amide I spectra of Aβ40 fibrils deposited for 15 min to 72 h on GM1/sphingomyelin/cholesterol (20:40:40) (A) and GlcCer/sphingomyelin/cholesterol (20:40:40) (B). The assigned peaks are summarized in C.
