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Proposed model of ganglioside-induced Aβ assembly in neural membranes, resulting in Alzheimer's disease. The formation of Aβ fibrils with parallel β-sheet on Aβ-sensitive ganglioside nanoclusters (ASIGN) (a–e) is faster than self-assembled oligomers with antiparallel β-sheet (f and g). Steps d and e are shown in Fig. 5A. Steps f and g are shown in Figs. 5B and 6A, respectively. GAβ, ganglioside-bound Aβ complex on ASIGN.
