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. 2018 Jul 24;293(36):13974–13988. doi: 10.1074/jbc.RA118.003541

Figure 7.

Figure 7.

Plin1−/− mice exhibit improved insulin resistance upon macrophage depletion. A and B, clodronate (100 μl dose for 20–25 g of mouse) was intraperitoneally injected to Plin1+/+ or Plin1−/− mice. Gene expression by qRT-PCR using macrophage markers (A) and histological analysis (B) are shown. Scale bars, 50 μm. ***, p < 0.001 versus Plin1+/+, vehicle group by two way-ANOVA followed by Bonferroni's post hoc test. C and D, ITT was performed 4 days after the injection of clodronate. *, p < 0.05 versus Plin1+/+, vehicle group by repeated measures-ANOVA followed by Bonferroni's post hoc test. All data represent the mean ± S.E. All qRT-PCR data were normalized to the mRNA level of cyclophilin. Veh, vehicle; Clo, clodronate; N.S., not significant.