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. 2018 Jul 2;293(36):14178–14189. doi: 10.1074/jbc.RA118.003613

Figure 2.

Figure 2.

Monoallelic deletion does not affect Lkb1 deletion-mediated improvements in glucose tolerance and augmented insulin secretion in males. A, oral glucose (2 g/kg) tolerance measurements were performed as described under “Experimental procedures” (n = 9–12 mice/genotype). p values were statistically determined by a two-way ANOVA test with a Bonferroni post-test (**, p < 0.01 and ****, p < 0.0001 βLkb1-KO versus control; †, p < 0.05 and ††††, p < 0.0001 βLkb1-KO-Tcf7l2-het versus control; p = 0.623 βLkb1-KO versus βLkb1-KO-Tcf7l2-het). B, area under the curve (AUC) for oral glucose tolerance tests (*, p < 0.05 βLkb1-KO versus control; **, p < 0.01 βLkb1-KO-Tcf7l2-het versus control). C, insulin plasma levels were measured in vivo 15 min after intraperitoneal injection of glucose (3 g/kg) (n = 7–9 mice/genotype; *, p < 0.05 and **, p < 0.01 versus 15-min control). D, insulin secretion in vitro was measured from groups of 10 size-matched isolated islets during static incubation (see “Experimental procedures”) and at the indicated glucose or KCl concentrations (n = 4 independent experiments; **, p < 0.01 βLkb1-KO-Tcf7l2-het versus βLkb1-KO; ***, p < 0.001 βLkb1-KO-Tcf7l2-het versus control). Error bars represent the mean ±S.E.; ns, not significant.