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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Alzheimers Dement. 2018 May 24;14(9):1193–1203. doi: 10.1016/j.jalz.2018.04.010
Estimate Std Error t value p value
Model: Sex
Time2 0.03 0.01 2.70 <0.001
Baseline PACC-5 −0.21 0.03 −6.18 <0.001
Age −0.01 0.003 −3.07 0.01
Education 0.01 0.007 1.95 0.07
Sex 0.11 0.04 2.74 0.003
Cohort −0.03 0.02 −1.28 0.42
Cohort*time2 0.02 0.001 9.26 <0.001
Baseline PACC-5*time2 0.003 0.002 1.68 0.06
Age*time2 −0.001 0.0001 −6.25 <0.001
Education*time2 0.0004 0.0003 1.12 0.24
Sex*time2 −0.003 0.002 −1.99 0.05
Model: Aβ*Sex
Time2 0.07 0.01 4.59 <0.001
Baseline PACC-5 −0.22 0.01 −6.62 <0.001
Age −0.009 0.003 −2.90 0.02
Education 0.02 0.007 2.32 0.02
Aβ −0.31 0.17 −1.79 0.07
Sex 0.02 0.24 0.06 0.95
Cohort −0.03 0.02 −1.29 0.41
Cohort*time2 0.01 0.001 8.90 <0.001
Baseline PACC-5*time2 0.001 0.002 0.82 0.41
Age*time2 −0.0008 0.0002 −4.95 <0.001
Education*time2 0.0002 0.0004 0.62 0.54
Aβ*Sex 0.10 0.23 0.44 0.66
Aβ*time2 −0.04 0.01 −5.09 <0.001
Sex*time2 0.03 0.01 2.58 0.01
Aβ*Sex*time2 −0.03 0.01 −2.96 0.003
Model: APOEε4*Sex
Time2 0.05 0.01 3.51 <0.001
Baseline PACC-5 −0.21 0.03 −5.98 <0.001
Age −0.01 0.003 −2.97 0.003
Education 0.02 0.01 2.11 0.04
APOEε4 −0.03 0.07 −0.48 0.63
Sex 0.11 0.05 2.24 0.03
Cohort −0.03 0.02 −1.36 0.40
Cohort*time2 0.01 0.001 9.24 <0.001
Baseline PACC-5*time2 0.003 0.002 1.59 0.11
Age*time2 −0.001 0.0001 −6.66 <0.001
Education*time2 0.0003 0.0003 0.83 0.40
APOEε4*time2 −0.01 0.004 −3.95 0.001
Sex*time2 −0.006 0.003 −2.30 0.02
APOEε4*Sex*time2 0.006 0.005 1.32 0.19
Model: Aβ*Sex*APOEε4
Time2 0.06 0.02 3.36 <0.001
Baseline PACC-5 −0.16 0.03 −5.47 <0.001
Age −0.009 0.003 −3.15 0.002
APOEε4 0.45 0.34 1.31 0.19
Education 0.01 0.006 2.04 0.04
Aβ −0.03 0.21 −0.13 0.90
Sex 0.31 0.29 1.09 0.28
Cohort −0.03 0.02 −1.23 0.43
Cohort*time2 0.01 0.001 8.33 <0.001
Baseline PACC-5*time2 0.0003 0.002 0.15 0.88
Age*time2 −0.0007 0.0002 −4.42 <0.0001
APOEε4*time2 0.02 0.02 0.99 0.32
Education*time2 0.0003 0.0003 0.91 0.36
Aβ*time2 −0.03 0.01 −2.24 0.03
Sex*time2 0.04 0.02 2.30 0.02
Aβ*Sex*time2 −0.04 0.02 −2.44 0.01
Aβ*APOEε4*time2 −0.02 0.02 −1.17 0.23
Sex*APOEε4*time2 −0.03 0.02 −1.43 0.15
APOEε4*Aβ*Sex 0.42 0.41 1.03 0.30
Aβ*Sex*APOEε4*time2 0.03 0.02 1.37 0.17
Model: Aβ*Sex*Age
Time2 0.19 0.09 2.14 0.03
Baseline PACC-5 −0.16 0.03 −5.73 <0.001
Age −0.001 0.02 −0.04 0.96
Education 0.01 0.006 2.10 0.04
Aβ 0.42 1.79 0.24 0.81
Sex 0.51 2.49 0.20 0.84
Cohort −0.03 0.02 −1.30 0.42
Cohort*time2 0.01 0.001 8.89 <0.001
Baseline PACC-5*time2 0.0009 0.002 0.52 0.60
Age*time2 −0.002 0.001 −1.91 0.06
Education*time2 0.0001 0.0003 0.45 0.65
Aβ*time2 −0.17 0.09 −2.41 0.02
Sex*time2 −0.31 0.13 −2.41 0.01
Aβ*Sex*time2 0.32 0.12 2.60 0.009
Aβ*Age *time2 0.002 0.001 1.54 0.12
Sex*Age*time2 0.004 0.002 2.57 0.01
Age*Aβ*Sex 0.008 0.03 0.25 0.80
Aβ*Sex*Age* time2 −0.005 0.002 −2.80 0.005
Model: Comparisons across Aβ status/APOEε4/Sex groups
Aβ−/APOEε4−/M*Time2 vs Aβ−/APOEε4−/F*Time2 0.001 0.002 0.36 0.72
Aβ−/APOEε4+/M*Time2 vs Aβ−/APOEε4+/F*Time2 −0.004 0.005 −0.78 0.43
Aβ+/APOEε4−/M*Time2 vs Aβ+/APOEε4−/F*Time2 −0.009 0.005 −1.85 0.06
Aβ+/APOEε4+/M*Time2 vs Aβ+/APOEε4+/F*Time2 −0.009 0.005 −2.04 0.04

Note: Aβ is the FBP SUVrequiv. Aβ+/− is formed according to the Aβ SUVr cut off = 1.082