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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Curr Opin Microbiol. 2018 Mar 10;45:61–69. doi: 10.1016/j.mib.2018.02.010

Figure 4.

Figure 4

New-to-nature hybrid RiPPs generated through RiPP engineering. By leveraging knowledge of substrate recognition from various RiPP classes, chimeric precursor peptides have been designed to recruit biosynthetic enzymes not naturally found in the same context. The resulting hybrid RiPPs have functional groups not currently found together in any natural product such as thiazolines/lanthionines, thiazolines/sactionines, and thiazolines/lanthionines/D-Ala; the latter is generated by enzymatic reduction of Dha.