Table 3.
Hemoglobin types and fractions found among 350 newborns in corresponding to genotypes. Values are presented as mean ± SD or as raw data where appropriate.
| Hb types (n°) | Genotype (n°) | Hb fraction (%) | ||||
|---|---|---|---|---|---|---|
| Hb A2 | Hb E | Hb F | Hb A | Hb Bart’s | ||
| FA (183) | αα/αα (145) | - | - | 84.2 ± 4.5 | 15.8 ± 4.5 | - |
| -α/αα (33) | - | - | 81.5 ± 5.2 | 18.8 ± 5.2 | - | |
| αTα/αα (4) | - | - | 82.9 ± 4.8 | 17.2 ± 4.8 | - | |
| αα/αα, β17βA (1) | - | - | 92.9 | 7.1 | - | |
| FABart’s (18) | -α/αα (4) | - | - | 82.0 ± 1.3 | 17.6 ± 1.3 | 0.4 ± 0.1 |
| αTα/αα (6) | - | - | 87.6 ± 1.5 | 11.8 ± 1.6 | 0.7 ± 0.2 | |
| -α/-α (4) | - | - | 79.3 ± 7.2 | 19.8 ± 7.1 | 0.9 ± 0.3 | |
| -α/αTα (1) | - | - | 84.5 | 9.7 | 5.8 | |
| --/αα (2) | - | - | 83.7, 89.5 | 14.3, 9.6 | 2, 0.9 | |
| --/-α (1) | - | - | 47.1 | 30 | 21.9 | |
| FABart’sH (1) * | --/-α (1) | - | - | 59.9 | 21.5 | 18.6 |
| CSFABart’s (1)** | αTα/αα (1) | - | - | 94.8 | 4.4 | 0.6 |
| A2FA (25) | αα/αα (21) | 0.2 ± 0.2 | - | 75.4 ± 6.9 | 24.3 ± 6.8 | - |
| -α/αα (3) | 0.4 ± 0.1 | - | 70.2 ± 8.0 | 29.4 ± 7.9 | - | |
| αα/αα, β17βA (1) | 0.2 | - | 86.8 | 13 | - | |
| A2FABart’s (4) | -α/αα (1) | 0.1 | - | 78.4 | 21.2 | 0.3 |
| αTα/αα (1) | 0.1 | - | 80.8 | 18.4 | 0.7 | |
| --/αα (2) | 0.3, 0.2 | - | 62.7, 67.7 | 34.2, 27.9 | 2.8, 4.1 | |
| CSA2FABart’s (2) ** | αTα/αα (2) | 0.3, 0.1 | - | 71.6, 78.1 | 27.4, 20.8 | 0.5, 0.8 |
| EF (14) | αα/αα, βEβE (8) | - | 6.5 ± 2.8 | 93.4 ± 2.9 | - | - |
| -α/αα, βEβE (6) | 0.7 ± 0.7 | 12.7 ± 8.7 | 87.0 ± 9.3 | - | - | |
| EFBart’s (6) | αα/αα, βEβE (2) | 0.1, - | 8.7, 5.5 | 91.2, 94.5 | - | 0.3, 0.4 |
| -α/αα, βEβE (2) | - | 3.7, 3.2 | 95.9, 96.5 | - | 0.4, 0.3 | |
| -α/-α, βEβE (1) | - | 6.8 | 90.8 | - | 2.4 | |
| -α/αTα, βEβE (1) | 0.4 | 12.2 | 83.7 | - | 3.7 | |
| EFA (80) | αα/αα, βEβA (60) | 0.4 ± 0.1 | 3.5 ± 1.3 | 88.3 ± 4.8 | 8.2 ± 3.5 | - |
| -α/αα, βEβA (19) | 0.2 ± 0.1 | 3.5 ± 1.0 | 86.9 ± 4.5 | 9.6 ± 3.5 | - | |
| αTα/αα, βEβA (1) | - | 4.7 | 82.1 | 13.2 | - | |
| EFABart’s (14) | -α/αα, βEβA (2) | 0.2, - | 3.7, 2.2 | 81.3, 92.0 | 14.3, 5.8 | 0.5, 0.2 |
| αTα/αα, βEβA (4) | - | 3.3 ± 0.8 | 87.5 ± 2.7 | 8.6 ± 2.1 | 0.6 ± 0.2 | |
| -α/-α, βEβA (2) | 0.4, - | 5.2, 5.6 | 75.8, 87.7 | 16.8, 8.7 | 1.8, 1.3 | |
| -α/αTα, βEβA (1) | - | 1.6 | 87.1 | 5.7 | 5.6 | |
| --/αα, βEβA (5) | - | 3.3 ± 0.7 | 81.5 ± 4.0 | 12.2 ± 3.6 | 3.0 ± 1.5 | |
| CSEFABart’s (2) *** | -α/αTα, βEβA (2) | - | 2.4, 1.2 | 84.4, 85.7 | 8.6, 3.5 | 4.2, 9.2 |
αTα: αCSα or αPSα.
*
Level of Hb H fraction = 0.8%.
Level of Hb CS fraction:
**
= 0.2% in all three cases,
***
= 0.4% in both cases.