Table 2.
Details of octreotide therapy
| Case | Indication for octreotide | Age at start of treatment (days) | Duration of treatment (days) | Route and frequency | Duration of drainage | Initial dose | Days to initiate octreotide after effusion | Maximum dose | Adverse effects | Response |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Chylothorax [acquired] Bilateral |
21 | 22 | Intravenous continuous infusion | 28 | 1 µg/kg/h | 6 | 10 µg/kg/h | a. Transient decrease in thyroid-stimulating hormone b. Transient hyperglycaemia |
Yes |
| 2 | Chylothorax [acquired] Bilateral |
18 | 23 | Intravenous continuous infusion | 26 | 1 µg/kg/h | 4 | 10 µg/kg/h | a. Transient decrease in free thyroxine b. Transient hyperglycaemia |
No |
| 3 | Chylous ascites [acquired] | 82 | 7 | Intravenous continuous infusion | 27 | 1 µg/kg/h | 20 | 4 µg/kg/h | No adverse effect | Yes |
| 4 | Chylothorax [acquired] Bilateral |
72 | 26 | Intravenous continuous infusion | 53 | 1 µg/kg/h | 27 | 10 µg/kg/h | a. Transient hyperglycaemia b. Transient decrease in free thyroxine and thyroid-stimulating hormone |
Yes |
| 5 | Chylothorax [congenital] Bilateral |
17 | 9 | Intravenous continuous infusion | 25 | 1 µg/kg/h | 18 | 10 µg/kg/h | a. Decrease in free T4 | No |
| 6 | Chylothorax [acquired] Unilateral left |
16 | 13 | Intravenous continuous infusion | 12 | 1 µg/kg/h | 8 | 4 µg/kg/h | a. Transient hyperglycaemia | Yes |
| 7 | Chylothorax [congenital] Bilateral |
25 | 29 | Intravenous continuous infusion | 65 | 1 µg/kg/h | 24 | 8 µg/kg/h | No adverse effect | No |
| 8 | Chylous ascites [congenital] | 21 | 28 | Intravenous continuous infusion | 42 | 1 µg/kg/h | 16 | 8 µg/kg/h | a. Transient hyperglycaemia | No |
| 9 | Chylothorax [acquired] Bilateral |
68 | 66 | Intravenous continuous infusion | 57 | 1 µg/kg/h | 22 | 8 µg/kg/h | a. Transient hyperglycaemia | No |
| 10 | Chylothorax [idiopathic] Unilateral left |
64 | 10 | Subcutaneous injection in three divided doses | 40 | 25 µg/kg/day | 13 | 117 µg/kg/day | a. Decrease in free thyroxine and thyroid-stimulating hormone | No |
| 11 | Chylothorax [congenital] Unilateral right |
24 | 5 | Subcutaneous injection in three divided doses | 23 | 11 µg/kg/day | 10 | 24 µg/kg/day | No adverse effects | No |