Table 2.

Final epithelial lining fluid population pharmacokinetic model parameters for ceftazidime and avibactam

Drug	Parameter	Median	5th percentile	95th percentile	CV %
Ceftazidime	EMAX, mg/l	45.4 ± 12%	30.9	66.5	24
	KM, mg/l	71.7 ± 22%	18.8	273.3	97
	RESMELF	0.101	0	0	0
Avibactam	EPR (1 mg/l)	0.472 ± 11%	0.172	1.298	68
	POW	0.860 ± 5%	0.588	1.259	23
	RESMELF	0.117	0	0	0

CV coefficient of variation, ELF epithelial lining fluid, EPR (1 mg/l) ELF penetration ratio at plasma concentration of 1 mg/l, E_MAX maximal concentration, K_M Michaelis–Menten constant, POW power term, RESM_ELF residual noise (median) for ELF, K_ELF rate constant for ELF